About the CRUSADE Initiative

Launched in 2001, the CRUSADE Quality Improvement Initiative was designed to increase the practice of evidence-based medicine for patients diagnosed with non-ST segment elevation acute coronary syndromes (NSTE ACS) (i.e., unstable angina or NSTE myocardial infarction). The CRUSADE Quality Improvement Initiative included maintenance of a database of high-risk NSTE ACS patients admitted to U.S. hospitals from November 2001 through January 2007. Inclusion criteria for enrollment into CRUSADE included ischemic symptoms lasting =10 minutes combined with positive cardiac biomarkers (CK-MB or Troponin I or T > upper limit of normal for the local laboratory assay) or ischemic ST-segment electrocardiograph changes (ST depression or transient ST-segment elevation). CRUSADE hospitals are diverse in size, teaching status, capacity, and region. Participating hospitals collected detailed process of care and in-hospital outcomes data through retrospective chart review using a standardized data collection form. Data include demographic and clinical information, medical history, use of antiplatelet, anti-thrombin and anti-ischemic therapies and use of invasive procedures, laboratory results, in-hospital outcomes, physician and hospital characteristics, and discharge medications and interventions.